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Abou El-Ala, K., Shehata, A., Magdy, A. (2013). EFFECT OF METHYLENE BLUE TREATMENT AFTER SEPSIS INDUCED BY CECAL LIGATION AND PUNCTURE IN ALBINO RAT MODELS. Egyptian Journal of Zoology, 60(60), 37-52. doi: 10.12816/0003282
K. S. Abou El-Ala; A. M. Shehata; A. Magdy. "EFFECT OF METHYLENE BLUE TREATMENT AFTER SEPSIS INDUCED BY CECAL LIGATION AND PUNCTURE IN ALBINO RAT MODELS". Egyptian Journal of Zoology, 60, 60, 2013, 37-52. doi: 10.12816/0003282
Abou El-Ala, K., Shehata, A., Magdy, A. (2013). 'EFFECT OF METHYLENE BLUE TREATMENT AFTER SEPSIS INDUCED BY CECAL LIGATION AND PUNCTURE IN ALBINO RAT MODELS', Egyptian Journal of Zoology, 60(60), pp. 37-52. doi: 10.12816/0003282
Abou El-Ala, K., Shehata, A., Magdy, A. EFFECT OF METHYLENE BLUE TREATMENT AFTER SEPSIS INDUCED BY CECAL LIGATION AND PUNCTURE IN ALBINO RAT MODELS. Egyptian Journal of Zoology, 2013; 60(60): 37-52. doi: 10.12816/0003282

EFFECT OF METHYLENE BLUE TREATMENT AFTER SEPSIS INDUCED BY CECAL LIGATION AND PUNCTURE IN ALBINO RAT MODELS

Article 3, Volume 60, Issue 60, December 2013, Page 37-52  XML
Document Type: Original Research Papers
DOI: 10.12816/0003282
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Authors
K. S. Abou El-Ala; A. M. Shehata; A. Magdy email
Biological Sector, National Organization for Drug Control and Research, Cairo, Egypt
Abstract
The purpose of this study was to investigate the possible therapeutic potential of methylene blue (MB) against sepsis induced by cecal ligation and puncture (CLP) in adult female albino rat models. Rats were intraperitoneally injected with single dose of 1 mg/kg body weight/day for 15 days. Arterial blood samples were withdrawn at time intervals of 1, 5, 10 and 15 days. The present results showed that CLP induced blood sepsis accompanied with inflammatory reactions in terms of increased blood leucocytes count, elevated levels of erythrocyte sedimentaion rate, c-reactive protein and IgG. In addition, blood sepsis induced oxidative stress in terms of decreased level of reduced glutathione and increased level of malondialdehyde indicating lipid peroxidation. MB treatment showed a beneficial effect in minimizing the adverse effect of CLP.
Keywords
Sepsis; Cecal ligation and puncture; methylene blue; Oxidative Stress; Inflammation
Main Subjects
Animal Physiology
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