Allam, M., Aly, F., Mar'ie, Z. (2021). IMPACT OF CURCUMIN AND VIRGIN OLIVE OIL AGAINST LEAD ACETATE-INDUCED GENETIC VARIATION IN THE MAJOR HISTOCOMPATIBILITY COMPLEX REGION IN MICE. Egyptian Journal of Zoology, 76(76), 66-75. doi: 10.21608/ejz.2021.88079.1063
Mohammad Allam; Fayza M. Aly; Zeinab A. Mar'ie. "IMPACT OF CURCUMIN AND VIRGIN OLIVE OIL AGAINST LEAD ACETATE-INDUCED GENETIC VARIATION IN THE MAJOR HISTOCOMPATIBILITY COMPLEX REGION IN MICE". Egyptian Journal of Zoology, 76, 76, 2021, 66-75. doi: 10.21608/ejz.2021.88079.1063
Allam, M., Aly, F., Mar'ie, Z. (2021). 'IMPACT OF CURCUMIN AND VIRGIN OLIVE OIL AGAINST LEAD ACETATE-INDUCED GENETIC VARIATION IN THE MAJOR HISTOCOMPATIBILITY COMPLEX REGION IN MICE', Egyptian Journal of Zoology, 76(76), pp. 66-75. doi: 10.21608/ejz.2021.88079.1063
Allam, M., Aly, F., Mar'ie, Z. IMPACT OF CURCUMIN AND VIRGIN OLIVE OIL AGAINST LEAD ACETATE-INDUCED GENETIC VARIATION IN THE MAJOR HISTOCOMPATIBILITY COMPLEX REGION IN MICE. Egyptian Journal of Zoology, 2021; 76(76): 66-75. doi: 10.21608/ejz.2021.88079.1063
IMPACT OF CURCUMIN AND VIRGIN OLIVE OIL AGAINST LEAD ACETATE-INDUCED GENETIC VARIATION IN THE MAJOR HISTOCOMPATIBILITY COMPLEX REGION IN MICE
1Zoology Department, Faculty of Science, South Valley University, Qena, Egypt
2Science Department, Faculty of Education, South Valley University, Hurghada, Red Sea, Egypt
Abstract
Lead acetate – which results in significant damage to the genetic structure of living organisms – is found in many sources that humans use daily. Histocompatibility complex (MHC) genes in the vertebrate play a critical role in immune responses, and are highly polymorphic. Virgin olive oil (VOO) and curcumin are natural compounds having several healthy features including antigenotoxic activities. The present study aimed for determining the effects of VOO and curcumin (versus ZnCl2, as an antioxidant agent) on Mhc genetic variation of renal tissues of lead acetate-treated mice by using the microsatellite loci. Thirty male albino Swiss mice (Mus musculus) were randomly allotted into 5 groups (n = 6): group “1”, the control group; groups “2–5” that received orally lead acetate (400 mg/kg body weight, by gavage for 15 consecutive days) + either distilled water (orally), or ZnCl2 (4 mg/kg body weight, intraperitoneally injected), or curcumin (500 mg/kg body weight, orally), or VOO (8 mL/kg body weight, orally) for additional 15 consecutive days, respectively. Comparing to the control group, the 2nd and the 4th groups showed high polymorphism value (17%) and (21%), respectively; while the 3rd and 5th groups showed low polymorphism value (12%) and (15%), respectively, in Mhc genes. The obtained data illustrated the usefulness of virgin olive oil, as compared with the curcumin, in limiting Mhc genetic variation induced by lead acetate in mice.
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